KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis.

ABSTRACT:

Background

Fibroblast-like synoviocytes (FLS) and CCR7^- effector memory T (T_EM) cells are two of the major cell types implicated in the progression of rheumatoid arthritis (RA). In particular, FLS become highly invasive, whereas T_EM cells proliferate and secrete proinflammatory cytokines, during RA. FLS and T cells may also interact and influence each other's phenotypes. Inhibition of the pathogenic phenotypes of both FLS and T_EM cells can be accomplished by selectively blocking the predominant potassium channels that they upregulate during RA: KCa1.1 (BK, Slo1, MaxiK, KCNMA1) upregulated by FLS and Kv1.3 (KCNA3) upregulated by activated T_EM cells. In this study, we investigated the roles of KCa1.1 and Kv1.3 in regulating the i

SUBMITTER: Tanner MR 

PROVIDER: S-EPMC6322314 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature