Noninvasive molecular diagnosis of craniopharyngioma with MRI-based radiomics approach.

ABSTRACT:

Background

Frequent somatic mutations of BRAF and CTNNB1 were identified in both histological subtypes of craniopharyngioma (adamantinomatous and papillary) which shed light on target therapy to cure this oncogenic disease. The aim of this study was to investigate the noninvasive MRI-based radiomics diagnosis to detect BRAF and CTNNB1 mutations in craniopharyngioma patients.

Methods

Forty-four patients pathologically diagnosed as adamantinomatous craniopharyngioma (ACP) or papillary craniopharyngioma (PCP) were retrospectively studied. High-throughput features were extracted from manually segmented tumors in MR images of each case. The modifications-robustness in region of interests and Random Forest-based feature selection methods were adopted to select the most significant

SUBMITTER: Chen X 

PROVIDER: S-EPMC6322318 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature