Sex-related DNA methylation differences in B cell chronic lymphocytic leukemia.

ABSTRACT:

Background

Men are at higher risk of developing chronic lymphocytic leukemia (CLL) than women. DNA methylation has been shown to play important roles in a number of cancers. There are differences in the DNA methylation pattern between men and women. In this study, we investigated whether this contributes to the sex-related difference of B cell CLL risk.

Methods

Using the HumanMethylation450 BeadChip, we profiled the genome-wide DNA methylation pattern of CD19⁺ B cells from 48 CLL patients (29 female patients and 19 male patients) and 28 healthy people (19 women and 9 men).

Results

We identified 1043 sex-related differentially methylated positions (DMPs) related to CLL, 56 of which are located on autosomes and 987 on the X chromosome. Using published B cell

SUBMITTER: Lin S 

PROVIDER: S-EPMC6322323 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature