Skeletal Muscle Fibrosis in Pancreatic Cancer Patients with Respect to Survival.

ABSTRACT:

Background

Cancer cachexia is a catabolic condition characterized by skeletal muscle wasting, consequent to tumor burden, which negatively impacts tolerance to cancer therapies and contributes to increased mortality. Partly because of the limited knowledge of the underlying mechanisms of cancer cachexia derived from human studies, however, the ability to therapeutically intervene remains elusive. The purpose of the current study was therefore to better define the phenotype of skeletal muscle obtained from patients with pancreatic ductal adenocarcinoma (PDAC), which has one of the highest rates of cachexia.

Methods

Morphological analyses were performed on rectus abdominis muscle biopsies obtained from resectable PDAC patients undergoing tumor resection surgery (N = 20) and fr

SUBMITTER: Judge SM 

PROVIDER: S-EPMC6322478 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature