Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.

ABSTRACT: We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T-cells within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6322556 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature