DMTS is an effective treatment in both inhalation and injection models for cyanide poisoning using unanesthetized mice.

ABSTRACT:

Context

Cyanide (CN) is a metabolic poison, halting ATP synthesis by inhibiting complex IV of the electron transport chain. If exposed at high enough concentrations, humans and most animals can die within minutes. Because time is a crucial factor in survival of CN poisoning, a rapidly bioavailable, nontoxic, easy to administer CN medical countermeasure could improve morbidity/mortality in a mass CN exposure scenario. The most likely route of exposure to CN is via inhalation.

Objective

This study examined the efficacy of a new formulation for dimethyl trisulfide (DMTS), a countermeasure which has shown promise as a treatment for CN poisoning, using both inhalation and injection models of CN exposure.

Methods

We developed a model of acute CN inhalation intoxication, usi

SUBMITTER: DeLeon SM 

PROVIDER: S-EPMC6322672 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature