Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution.

ABSTRACT:

Background

Idarucizumab is a humanized Fab fragment that specifically reverses dabigatran anticoagulation. In trauma, volume expanders are used for resuscitation to compensate for blood loss and hemorrhagic shock, but it is unknown whether volume expanders influence the binding of dabigatran to its antidote. Using a porcine dilutional coagulopathy model, this study investigated whether volume replacement strategies affect binding of dabigatran to idarucizumab.

Methods

Twenty-five male pigs were treated orally with dabigatran etexilate (30 mg/kg bid) for 3 days. The following day, animals were anesthetized, infused with dabigatran (total dose 0.645 mg/kg) to achieve supratherapeutic concentrations, and randomized 1:1:1:1:1 (n = 5 per group) to control (no hemodilution) or hem

SUBMITTER: Grottke O 

PROVIDER: S-EPMC6322768 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature