Permissive underfeeding, cytokine profiles and outcomes in critically ill patients.

ABSTRACT:

Background

During critical illness in humans, the effects of caloric restriction on the inflammatory response are not well understood. The aim of this study is to examine the associations of caloric restriction, inflammatory response profiles and outcomes in critically ill patients.

Methods

This is a sub-study of the PermiT trial (Permissive Underfeeding or Standard Enteral Feeding in Critically Ill Adults Trial- ISRCTN68144998). Serum samples were collected on study days 1, 3, 5, 7 and 14 and analyzed for a panel of 29 cytokines. We used principal component analysis to convert possibly correlated variables (cytokine levels) into a limited number of linearly uncorrelated variables (principal components). We constructed repeated measures mixed linear models to assess whether

SUBMITTER: Arabi Y 

PROVIDER: S-EPMC6322779 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature