Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus.

ABSTRACT: Mutations in the genes encoding nuclear factor (erythroid-derived 2)-like 2 (NRF2), Kelch-like ECH-associated protein 1 (KEAP1), and cullin 3 (CUL3) are commonly observed in human esophageal squamous cell carcinoma (ESCC) and result in activation of the NRF2 signaling pathway. Moreover, hyperactivity of the transcription factor Nrf2 has been found to cause esophageal hyperproliferation and hyperkeratosis in mice. However, the underlying mechanism is unclear. In this study, we aimed to understand the molecular mechanisms of esophageal hyperproliferation in mice due to hyperactive Nrf2. Esophageal tissues were obtained from genetically modified mice that differed in the status of the Nrf2 gene and genes in the same pathway (Nrf2^-/-, Keap1^-/-, K5C

SUBMITTER: Fu J 

PROVIDER: S-EPMC6322899 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature