Antiangiogenic VEGF₁₆₅b Regulates Macrophage Polarization via S100A8/S100A9 in Peripheral Artery Disease.

ABSTRACT:

Background

Atherosclerotic occlusions decrease blood flow to the lower limbs, causing ischemia and tissue loss in patients with peripheral artery disease (PAD). No effective medical therapies are currently available to induce angiogenesis and promote perfusion recovery in patients with severe PAD. Clinical trials aimed at inducing vascular endothelial growth factor (VEGF)-A levels, a potent proangiogenic growth factor to induce angiogenesis, and perfusion recovery were not successful. Alternate splicing in the exon-8 of VEGF-A results in the formation of VEGFxxxa (VEGF₁₆₅a) and VEGFxxxb (VEGF₁₆₅b) isoforms with existing literature focusing on VEGF₁₆₅b's role in inhibiting vascular endothelial growth factor receptor 2-dependent angiogenesis. However,

SUBMITTER: Ganta VC 

PROVIDER: S-EPMC6322929 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature