Associations of Perioperative Renal Oximetry Via Near-Infrared Spectroscopy, Urinary Biomarkers, and Postoperative Acute Kidney Injury in Infants After Congenital Heart Surgery: Should Creatinine Continue to Be the Gold Standard?

ABSTRACT:

Objectives

Examine the relationship between perioperative renal regional tissue oximetry, urinary biomarkers, and acute kidney injury in infants after congenital cardiac surgery with cardiopulmonary bypass.

Design

Prospective, observational.

Setting

Cardiac operating room and cardiac ICU.

Patients

Neonates and infants without history of kidney injury or anatomic renal abnormality.

Interventions

None.

Measurements and main results

Renal regional tissue oximetry was measured intraoperatively and for 48 hours postoperatively. Urinary levels of neutrophil gelatinase-associated lipocalin and tissue inhibitor of metalloproteinases 2 together with insulin-like growth factor-binding protein 7 were measured preoperatively, 2, 12, and 24 hours postoperative

SUBMITTER: Adams PS 

PROVIDER: S-EPMC6322941 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature