Salience network connectivity and social processing in children with nonverbal learning disability or autism spectrum disorder.

ABSTRACT:

Objective

Nonverbal learning disability (NVLD) is a putative neurodevelopmental disorder characterized by spatial processing deficits as well as social deficits similar to those characteristic of autism spectrum disorder (ASD). Nonetheless, NVLD may be a distinct disorder that is differentially associated with the functioning and connectivity of the salience (SN) and default mode (DMN) networks that support social processing. Thus, we sought to assess and compare connectivity across these networks in children with NVLD, ASD, and typically developing children.

Method

Resting-state fMRI data were examined in 17 children with NVLD, 17 children with ASD selected from the Autism Brain Imaging Data Exchange (ABIDE), and 40 TD children (20 from ABIDE). Average DMN and SN functional

SUBMITTER: Margolis AE 

PROVIDER: S-EPMC6322976 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature