Acute Hepatic Porphyrias in Colombia: An Analysis of 101 Patients.

ABSTRACT:

Background

There is minimal information available about acute hepatic porphyrias (AHPs) in developing countries. The aim of this study was to describe the demographics, clinical features, and mortality of AHPs in Colombia.

Patients and methods

121 patients with presumed diagnosis of AHPs were reported in Colombia between 1944 and 2018. A pooled analysis of 53 patients with confirmed diagnosis was performed to evaluate the demographics, clinical features, and mortality of AHPs in the country. Selected variables were compared by periods (1952-2000 and 2001-2018).

Results

Most attacks occurred in women (66%), with a women-to-man ratio of 39/14. 96% of the patients were diagnosed with AHPs between 15 and 40 years of age. Precipitants were identified in 71% of attacks and

SUBMITTER: Jaramillo-Calle DA 

PROVIDER: S-EPMC6323027 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature