Elevated plasma glypicans are associated with organ failure in patients with infection.

ABSTRACT:

Background

Increased vascular permeability is a key feature in the pathophysiology of sepsis and the development of organ failure. Shedding of the endothelial glycocalyx is increasingly being recognized as an important pathophysiological mechanism but at present it is unclear if glypicans contribute to this response. We hypothesized that plasma levels of glypicans (GPC) are elevated in patients with sepsis.

Methods

Plasma GPC 1-6 levels were measured by ELISA in 10 patients with sepsis and 10 healthy controls as an initial screening. Plasma GPC 1, 3, and 4 were further measured in a cohort of 184 patients with a clinically confirmed infection. Patients were divided into groups of those who had sepsis and those who had an infection without organ failure. To determine whether

SUBMITTER: Fisher J 

PROVIDER: S-EPMC6323058 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature