Low-flow CO₂ removal in combination with renal replacement therapy effectively reduces ventilation requirements in hypercapnic patients: a pilot study.

ABSTRACT:

Background

Lung-protective strategies are the cornerstone of mechanical ventilation in critically ill patients with both ARDS and other disorders. Extracorporeal CO₂ removal (ECCO₂R) may enhance lung protection by allowing even further reductions in tidal volumes and is effective in low-flow settings commonly used for renal replacement therapy. In this study, we describe for the first time the effects of a labeled and certified system combining ECCO₂R and renal replacement therapy on pulmonary stress and strain in hypercapnic patients with renal failure.

Methods

Twenty patients were treated with the combined system which incorporates a membrane lung (0.32 m²) in a conventional renal replacement circuit. After changes in blood gases

SUBMITTER: Nentwich J 

PROVIDER: S-EPMC6323065 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature