Skin autofluorescence predicts incident type 2 diabetes, cardiovascular disease and mortality in the general population.

ABSTRACT:

Aims/hypothesis

Earlier studies have shown that skin autofluorescence measured with an AGE reader estimates the accumulation of AGEs in the skin, which increases with ageing and is associated with the metabolic syndrome and type 2 diabetes. In the present study, we examined whether the measurement of skin autofluorescence can predict 4 year risk of incident type 2 diabetes, cardiovascular disease (CVD) and mortality in the general population.

Methods

For this prospective analysis, we included 72,880 participants of the Dutch Lifelines Cohort Study, who underwent baseline investigations between 2007 and 2013, had validated baseline skin autofluorescence values available and were not known to have diabetes or CVD. Individuals were diagnosed with incident type 2 diabetes by sel

SUBMITTER: van Waateringe RP 

PROVIDER: S-EPMC6323092 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature