Increased NEFA levels reduce blood Mg²⁺ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg².

ABSTRACT:

Aims/hypothesis

The blood triacylglycerol level is one of the main determinants of blood Mg²⁺ concentration in individuals with type 2 diabetes. Hypomagnesaemia (blood Mg²⁺ concentration <0.7 mmol/l) has serious consequences as it increases the risk of developing type 2 diabetes and accelerates progression of the disease. This study aimed to determine the mechanism by which triacylglycerol levels affect blood Mg²⁺ concentrations.

Methods

Using samples from 285 overweight individuals (BMI >27 kg/m²) who participated in the 300-Obesity study (an observational cross-sectional cohort study, as part of the Human Functional Genetics Projects), we investigated the association between serum Mg²⁺ with laboratory variables, includ

SUBMITTER: Kurstjens S 

PROVIDER: S-EPMC6323097 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature