Expression of miR‑542‑3p in osteosarcoma with miRNA microarray data, and its potential signaling pathways.

ABSTRACT: Osteosarcoma (OS) is the most common pediatric primary bone tumor, with high malignancy rates and a poor prognosis following metastasis. At present, the role of microRNA (miR)‑542‑3p in OS remains to be elucidated. The purpose of the present study was to investigate the expression level of miR‑542‑3p in OS, and its potential molecular mechanisms, via a bioinformatics analysis. First, the expression of miR‑542‑3p in OS based on the continuous variables of the Gene Expression Omnibus database and PubMed was studied. Subsequently, the potential target genes of miR‑542‑3p were predicted using gene expression profiles and bioinformatics software. On the basis of the Database for Annotation, Visualization and Integrated Discovery, version 6.8, a study of gene ontology (GO) enrichment and the Kyo

SUBMITTER: Li Z 

PROVIDER: S-EPMC6323234 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature