Enhanced Rg3 negatively regulates Th1 cell responses.

ABSTRACT:

Background

Korean Red Ginseng (KRG; Panax ginseng Meyer) is a widely used medicinal herb known to exert various immune modulatory functions. KRG and one of its purified components, ginsenoside Rg3, are known to possess anti-inflammatory activities. How they impact helper T cell-mediated responses is not fully explored. In this study, we attempted to evaluate the effect of KRG extract (KRGE) and ginsenoside Rg3 on Th1 cell responses.

Methods

Using well-characterized T cell in vitro differentiation systems, we examined the effects of KRGE or enhanced Rg3 on the Th1-inducing cytokine production from dendritic cells (DC) and the naïve CD4⁺ T cells differentiation to Th1 cells. Furthermore, we examined the change of Th1 cell population in the intestine af

SUBMITTER: Cho M 

PROVIDER: S-EPMC6323242 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature