The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.

ABSTRACT:

Objectives

GPR142, which is highly expressed in pancreatic islets, has recently been deorphanized as a receptor for aromatic amino acids; however, its physiological role and pharmacological potential is unclear.

Methods and results

We find that GPR142 is expressed not only in β- but also in α-cells of the islets as well as in enteroendocrine cells, and we confirm that GPR142 is a highly selective sensor of essential aromatic amino acids, in particular Trp and oligopeptides with N-terminal Trp. GPR142 knock-out mice displayed a very limited metabolic phenotype but demonstrated that L-Trp induced secretion of pancreatic and gut hormones is mediated through GPR142 but that the receptor is not required for protein-induced hormone secretion. A synthetic GPR142 agonist stimulated

SUBMITTER: Rudenko O 

PROVIDER: S-EPMC6323244 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature