VRK2, a Candidate Gene for Psychiatric and Neurological Disorders.

ABSTRACT: Recent large-scale genetic approaches, such as genome-wide association studies, have identified multiple genetic variations that contribute to the risk of mental illnesses, among which single nucleotide polymorphisms (SNPs) within or near the vaccinia related kinase 2 (VRK2) gene have gained consistent support for their correlations with multiple psychiatric and neurological disorders including schizophrenia (SCZ), major depressive disorder (MDD), and genetic generalized epilepsy. For instance, the genetic variant rs1518395 in VRK2 showed genome-wide significant associations with SCZ (35,476 cases and 46,839 controls, p = 3.43 × 10^-8) and MDD (130,620 cases and 347,620 controls, p = 4.32 × 10^-12) in European populations. This SNP was also g

SUBMITTER: Li M 

PROVIDER: S-EPMC6323383 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature