ASSOCIATION OF INTERLEUKIN-10 -592A>C AND -819T>C POLYMORPHISMS WITH GASTRIC CANCER RISK: A SYSTEMATIC REVIEW AND META-ANALYSIS OF 44 CASE-CONTROL STUDIES.

ABSTRACT:

Introduction

A series of studies have evaluated the association between -592A>C and -819T>C polymorphisms in the promoter regions of Interleukin-10 (IL-10) and gastric cancer (GC) risk. However, the results remain inconclusive.

Objective

To better understand the association of the polymorphisms with GC risk, we performed a comprehensive meta-analysis.

Method

An electronic search was performed of several databases to identify relevant studies up to April 2018.

Results

A total of 44 case-control studies, including 26 studies on IL-10 -592A>C (5,332 cases and 8,272 controls) and 18 studies on IL-10 -819T>C (3,431 cases and 6,109 controls) were selected. Overall, -592A>C polymorphism was associated with the risk of GC under the heterozygote model (OR=1.153, 95% CI=

SUBMITTER: Moghmi M 

PROVIDER: S-EPMC6323628 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature