Functional hypergraph uncovers novel covariant structures over neurodevelopment.

ABSTRACT: Brain development during adolescence is marked by substantial changes in brain structure and function, leading to a stable network topology in adulthood. However, most prior work has examined the data through the lens of brain areas connected to one another in large-scale functional networks. Here, we apply a recently developed hypergraph approach that treats network connections (edges) rather than brain regions as the unit of interest, allowing us to describe functional network topology from a fundamentally different perspective. Capitalizing on a sample of 780 youth imaged as part of the Philadelphia Neurodevelopmental Cohort, this hypergraph representation of resting-state functional MRI data reveals three distinct classes of subnetworks (hyperedges): clusters, bridges, and stars, which

SUBMITTER: Gu S 

PROVIDER: S-EPMC6323637 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature