A Population Pharmacokinetic Analysis to Study the Effect of Extracorporeal Membrane Oxygenation on Cefepime Disposition in Children.

ABSTRACT:

Objectives

Limited data exist on the effects of extracorporeal membrane oxygenation on pharmacokinetics of cefepime in critically ill pediatric patients. The objective was to describe cefepime disposition in children treated with extracorporeal membrane oxygenation using population pharmacokinetic modeling.

Design

Multicenter, prospective observational study.

Setting

The pediatric and cardiac ICUs of six sites of the Collaborative Pediatric Critical Care Research Network.

Patients

Seventeen critically ill children (30 d to < 2 yr old) on extracorporeal membrane oxygenation who received cefepime as standard of care between January 4, 2014, and August 24, 2015, were enrolled.

Interventions

None.

Measurements and main results

A pharmacokinetic model

SUBMITTER: Zuppa AF 

PROVIDER: S-EPMC6323642 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature