Human Atrial Fibrillation Drivers Resolved With Integrated Functional and Structural Imaging to Benefit Clinical Mapping.

ABSTRACT:

Objectives

This study sought to improve atrial fibrillation (AF) driver identification by integrating clinical multielectrode mapping with driver fingerprints defined by high-resolution ex vivo 3-dimensional (3D) functional and structural imaging.

Background

Clinical multielectrode mapping of AF drivers suffers from variable contact, signal processing, and structural complexity within the 3D human atrial wall, raising questions on the validity of such drivers.

Methods

Sustained AF was mapped in coronary-perfused explanted human hearts (n = 11) with transmural near-infrared optical mapping (∼0.3 mm² resolution). Simultaneously, custom FIRMap catheters (∼9 × 9 mm² resolution) mapped endocardial and epicardial surfaces, which were analyzed by Focal

SUBMITTER: Hansen BJ 

PROVIDER: S-EPMC6323649 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature