A modified subclassification to evaluate the survival of patients with N3 gastric cancer: an international database study.

ABSTRACT:

Background

The eighth TNM classification for gastric cancer categorizes N3 as N3a and N3b in the final pathologic stage. The cutoff for N3a/N3b is defined as 15 metastatic lymph nodes, but the rationale for this cutoff remains unclear. This study aimed to determine the optimal N3a/N3b cutoff and evaluate its prognostic significance.

Methods

An international database was constructed by combining data from patients with N3 gastric cancer and complete five-year follow-up data from the Surveillance, Epidemiology, and End Results program database (n = 1833) and the Fujian Medical University Union Hospital database (n = 920) (total n = 2753). A log-rank test was performed to determine the optimal N3a/N3b cutoff, and its prognostic significance was confirmed in a two-step multivari

SUBMITTER: Lin MQ 

PROVIDER: S-EPMC6323664 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature