Effect of fish oil supplement administration method on tolerability and adherence: a randomized pilot clinical trial.

ABSTRACT:

Objectives

Anecdotally, several strategies have been suggested in order to improve tolerability of fish oil supplements, but there is little evidence supporting any of these strategies. The aim of this study was to determine if there is a difference among four methods of oral administration of fish oil supplementation in terms of tolerability and adherence.

Methods

A randomized, prospective, open-label, four-arm pilot study was conducted on 60 healthy adult subjects randomized to different fish oil supplement administration methods with (1) milk, (2) food, (3) an empty stomach, and (4) frozen capsules prior to ingestion. Each subject was instructed to take two capsules three times daily for 30 consecutive days. Adherence was assessed by pill counts. Adverse effects were asse

SUBMITTER: Malinowski SS 

PROVIDER: S-EPMC6323689 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature