Interaction between TP53 and XRCC1 increases susceptibility to cervical cancer development: a case control study.

ABSTRACT:

Background

Cervical cancer is the 4th highest cause of female reproductive tract malignancies. Multiple loci have been identified as important determinant factors for tumor susceptibility. In this report, we aimed to explore the roles of gene polymorphisms affecting x-ray repair cross complementing 1 (XRCC1), the tumor protein p53 (TP53), and fibroblast growth factor receptor 3 (FGFR3) in the context of susceptibility to cervical cancer. Additionally, we assessed the impact of single nucleotide polymorphism-single nucleotide polymorphism (SNP-SNP) interaction of these three genes in the context of cervical cancer risk in Chinese women.

Methods

A case-control study consisted of 340 women located in Chongqing. Of these women, 121 were diagnosed with cervical cancer, 118 served

SUBMITTER: Liu GC 

PROVIDER: S-EPMC6323714 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature