Diversity of opisthokont septin proteins reveals structural constraints and conserved motifs.

ABSTRACT:

Background

Septins are cytoskeletal proteins important in cell division and in establishing and maintaining cell polarity. Although septins are found in various eukaryotes, septin genes had the richest history of duplication and diversification in the animals, fungi and protists that comprise opisthokonts. Opisthokont septin paralogs encode modular proteins that assemble into heteropolymeric higher order structures. The heteropolymers can create physical barriers to diffusion or serve as scaffolds organizing other morphogenetic proteins. How the paralogous septin modules interact to form heteropolymers is still unclear. Through comparative analyses, we hoped to clarify the evolutionary origin of septin diversity and to suggest which amino acid residues were responsible for subunit

SUBMITTER: Auxier B 

PROVIDER: S-EPMC6323724 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature