A panel of 32 AIMs suitable for population stratification correction and global ancestry estimation in Mexican mestizos.

ABSTRACT:

Background

Association studies are useful to unravel the genetic basis of common human diseases. However, the presence of undetected population structure can lead to both false positive results and failures to detect genuine associations. Even when most of the approaches to deal with population stratification require genome-wide data, the use of a well-selected panel of ancestry informative markers (AIMs) may appropriately correct for population stratification. Few panels of AIMs have been developed for Latino populations and most contain a high number of markers (> 100 AIMs). For some association studies such as candidate gene approaches, it may be unfeasible to genotype a numerous set of markers to avoid false positive results. In such cases, methods that use fewer AIMs may be ap

SUBMITTER: Huerta-Chagoya A 

PROVIDER: S-EPMC6323778 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature