Mycobacterium tuberculosis transmission in an ethnically-diverse high incidence region in England, 2007-11.

ABSTRACT:

Background

Transmission patterns in high tuberculosis incidence areas in England are poorly understood but need elucidating to focus contact tracing. We study transmission within and between age, ethnic and immigrant groups using molecular data from the high incidence West Midlands region.

Methods

Isolates from culture-confirmed tuberculosis cases during 2007-2011 were typed using 24-locus Mycobacterial Interspersed Repetitive Unit-Variable Number Tandem Repeats (MIRU-VNTR). We estimated the proportion of disease attributable to recent transmission, calculated the proportion of isolates matching those from the two preceding years ("retrospectively clustered"), and identified risk factors for retrospective clustering using multivariate analyses. We calculated the ratio (RCR)

SUBMITTER: Vynnycky E 

PROVIDER: S-EPMC6323781 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature