HIV-1 molecular transmission clusters in nine European countries and Canada: association with demographic and clinical factors.

ABSTRACT:

Background

Knowledge of HIV-1 molecular transmission clusters (MTCs) is important, especially in large-scale datasets, for designing prevention programmes and public health intervention strategies. We used a large-scale HIV-1 sequence dataset from nine European HIV cohorts and one Canadian, to identify MTCs and investigate factors associated with the probability of belonging to MTCs.

Methods

To identify MTCs, we applied maximum likelihood inferences on partial pol sequences from 8955 HIV-positive individuals linked to demographic and clinical data. MTCs were defined using two different criteria: clusters with bootstrap support >75% (phylogenetic confidence criterion) and clusters consisting of sequences from a specific region at a proportion of >75% (geographic criterion) co

SUBMITTER: Paraskevis D 

PROVIDER: S-EPMC6323837 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature