CD4: a vital player in the teleost fish immune system.

ABSTRACT: CD4 is a nonpolymorphic transmembrane glycoprotein molecule that is expressed on the surface of T-helper cells and plays an essential role in the immune response. It functions as a coreceptor with the T-cell receptor by binding to major histocompatibility complex class II on the surface of dendritic cells that present antigens. CD4⁺ T cells hold a key position in coordinating the immune system through production of several cytokines after activation and differentiation. The CD4⁺ T helper subtypes (T-helper 1, T-helper 2, T-helper 17, T-helper 9, and regulatory-T cells) perform different immune functions subsequent to their differentiation from the naive T cells. Different types of CD4⁺ T cells require different cytokines such as drivers and effectors, as we

SUBMITTER: Ashfaq H 

PROVIDER: S-EPMC6323851 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature