SCOPe: classification of large macromolecular structures in the structural classification of proteins-extended database.

ABSTRACT: The SCOPe (Structural Classification of Proteins-extended, https://scop.berkeley.edu) database hierarchically classifies domains from the majority of proteins of known structure according to their structural and evolutionary relationships. SCOPe also incorporates and updates the ASTRAL compendium, which provides multiple databases and tools to aid in the analysis of the sequences and structures of proteins classified in SCOPe. Protein structures are classified using a combination of manual curation and highly precise automated methods. In the current release of SCOPe, 2.07, we have focused our manual curation efforts on larger protein structures, including the spliceosome, proteasome and RNA polymerase I, as well as many other Pfam families that had not previously been classified. Domains

SUBMITTER: Chandonia JM 

PROVIDER: S-EPMC6323910 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature