ALEdb 1.0: a database of mutations from adaptive laboratory evolution experimentation.

ABSTRACT: Adaptive Laboratory Evolution (ALE) has emerged as an experimental approach to discover causal mutations that confer desired phenotypic functions. ALE not only represents a controllable experimental approach to systematically discover genotype-phenotype relationships, but also allows for the revelation of the series of genetic alterations required to acquire the new phenotype. Numerous ALE studies have been published, providing a strong impetus for developing databases to warehouse experimental evolution information and make it retrievable for large-scale analysis. Here, the first step towards establishing this resource is presented: ALEdb (http://aledb.org). This initial release contains over 11 000 mutations that have been discovered from eleven ALE publications. ALEdb (i) is a web-based

SUBMITTER: Phaneuf PV 

PROVIDER: S-EPMC6323966 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature