Association of Perfluoroalkyl and Polyfluoroalkyl Substances With Adiposity.

ABSTRACT:

Importance

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are ubiquitous synthetic chemicals that are suspected endocrine disruptors.

Objectives

To determine the extent to which PFASs are associated with increases in weight and body size and evaluate whether a lifestyle intervention modifies this association.

Design, setting, and participants

This prospective cohort study included 957 individuals who participated in the Diabetes Prevention Program trial, conducted from July 1996 to May 2001, and the Diabetes Prevention Program Outcomes Study, conducted from September 2002 to January 2014. Statistical analysis was conducted from September 1, 2017, to May 25, 2018.

Interventions and exposures

The initial lifestyle intervention consisted of training in diet

SUBMITTER: Cardenas A 

PROVIDER: S-EPMC6324277 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature