Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring.

ABSTRACT:

Importance

Valproate is an antiepileptic drug (AED) used in the treatment of epilepsy and many other neurological and psychiatric disorders. Its use in pregnancy is associated with increased risks of congenital malformations and adverse neurodevelopment in the offspring and may be associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD).

Objective

To determine whether prenatal exposure to valproate and other AEDs is associated with an increased risk of ADHD in the offspring.

Design, setting, and participants

This was a population-based cohort study of all live-born singleton children in Denmark from January 1, 1997, to December 31, 2011 (N = 913 302). Information on prenatal exposure to AEDs, including valproate, was obtained from the Danis

SUBMITTER: Christensen J 

PROVIDER: S-EPMC6324310 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature