Association Between Obesity and Cardiovascular Outcomes: A Systematic Review and Meta-analysis of Mendelian Randomization Studies.

ABSTRACT:

Importance

Although dyslipidemia has been consistently shown to be associated with atherogenesis, an association between obesity and cardiovascular disease outcomes remains controversial. Mendelian randomization can minimize confounding if variables are randomly and equally distributed in the population of interest.

Objective

To assess evidence from mendelian randomization studies to provide a less biased estimate of any association between obesity and cardiovascular outcomes.

Data sources

Systematic searches of MEDLINE and Scopus from database inception until January 2018, supplemented with manual searches of the included reference lists.

Study selection

Studies that used mendelian randomization methods to assess the association between any measure of obesity

SUBMITTER: Riaz H 

PROVIDER: S-EPMC6324374 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature