Exposure-Response Association Between Concurrent Opioid and Benzodiazepine Use and Risk of Opioid-Related Overdose in Medicare Part D Beneficiaries.

ABSTRACT:

Importance

Concurrent benzodiazepine use is associated with an increased risk of opioid-related overdose; however, it remains unknown how the overdose risk varies with the days of exposure to both medications.

Objective

To evaluate the exposure-response association between the days with concurrent prescription opioid and benzodiazepine use and the risk of overdose.

Design, setting, and participants

Retrospective cohort study of Medicare Part D claims data from January 1, 2013, to December 31, 2014. Analyses were conducted in fall 2017 and spring 2018. Participants were Medicare Part D beneficiaries who filled at least 1 prescription for an opioid in 2014.

Exposures

Patients were divided into 2 groups based on whether they had opioid and benzodiazepine supplies

SUBMITTER: Hernandez I 

PROVIDER: S-EPMC6324417 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature