Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response.

ABSTRACT:

Importance

The World Health Organization identified the need for a non-sputum-based triage test to identify those in need of further tuberculosis (TB) testing.

Objective

To determine whether the 3-gene TB score can be a diagnostic tool throughout the course of TB disease, from latency to diagnosis to treatment response, and posttreatment residual inflammation.

Design, setting, and participants

This nested case-control study analyzed the 3-gene TB score in 3 cohorts, each focusing on a different stage of TB disease: (1) the Adolescent Cohort Study profiled whole-blood samples from adolescents with latent Mycobacterium tuberculosis infection, some of which progressed to active TB (ATB), using RNA sequencing; (2) the Brazil Active Screen Study collected whole blood from

SUBMITTER: Warsinske HC 

PROVIDER: S-EPMC6324428 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature