Association of Prior Vaccination With Influenza Vaccine Effectiveness in Children Receiving Live Attenuated or Inactivated Vaccine.

ABSTRACT:

Importance

Some studies have reported negative effects of prior-season influenza vaccination. Prior-season influenza vaccination effects on vaccine effectiveness (VE) in children are not well understood.

Objective

To assess the association of prior-season influenza vaccination with subsequent VE in children aged 2 to 17 years.

Design, setting, and participants

This multiseason, test-negative case-control study was conducted in outpatient clinics at 4 US sites among children aged 2 to 17 years with a medically attended febrile acute respiratory illness. Participants were recruited during the 2013-2014, 2014-2015, and 2015-2016 seasons when influenza circulated locally. Cases were children with influenza confirmed by reverse-transcription polymerase chain reaction. Test

SUBMITTER: McLean HQ 

PROVIDER: S-EPMC6324442 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature