Trends in Risks for Second Primary Cancers Associated With Index Human Papillomavirus-Associated Cancers.

ABSTRACT:

Importance

In the last 4 decades, survival among patients with human papillomavirus (HPV)-associated cancers has improved, while the incidence of these cancers has increased among younger cohorts. Among survivors of HPV-associated cancers, persistent HPV infection may remain a risk factor for preventable HPV-associated second primary cancers (HPV-SPCs).

Objectives

To investigate the risk of HPV-SPCs among survivors of HPV-associated index cancers and to test the hypothesis that the HPV-SPC risk among these persons has increased over the last 4 decades.

Design, setting, and participants

A retrospective cohort study of 9 cancer registries of the Surveillance, Epidemiology, and End Results (SEER) database was conducted to identify patients with HPV-associated (cervical,

SUBMITTER: Suk R 

PROVIDER: S-EPMC6324459 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature