Incidence of Placebo Adverse Events in Randomized Clinical Trials of Targeted and Immunotherapy Cancer Drugs in the Adjuvant Setting: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Several reports have associated the placebo effect with objective response and improvement of a clinical condition in oncology, but only a few studies have analyzed the adverse events (AEs) in the placebo groups of the clinical trials.

Objective

To determine the incidence of placebo AEs reported in randomized clinical trials of modern cancer drugs in the adjuvant setting.

Data sources

Based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline, a systematic literature search of English-language publications from January 1, 2000, through April 15, 2018, was performed using MEDLINE (PubMed). The following search terms were used to retrieve all trials from the PubMed library: adjuvant, maintenance, consolidation

SUBMITTER: Chacon MR 

PROVIDER: S-EPMC6324542 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature