The acid-sensing ion channel ASIC1a mediates striatal synapse remodeling and procedural motor learning.

ABSTRACT: Acid-sensing ion channel 1a (ASIC1a) is abundant in multiple brain regions, including the striatum, which serves as the input nucleus of the basal ganglia and is critically involved in procedural learning and motor memory. We investigated the functional role of ASIC1a in striatal neurons. We found that ASIC1a was critical for striatum-dependent motor coordination and procedural learning by regulating the synaptic plasticity of striatal medium spiny neurons. Global deletion of Asic1a in mice led to increased dendritic spine density but impaired spine morphology and postsynaptic architecture, which were accompanied by the decreased function of N-methyl-d-aspartate (NMDA) receptors at excitatory synapses. These structural and functional changes caused by the loss of ASIC1a were

SUBMITTER: Yu Z 

PROVIDER: S-EPMC6324561 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature