Ethical Acceptability of Postrandomization Consent in Pragmatic Clinical Trials.

ABSTRACT:

Importance

Pragmatic clinical trials that seek informed consent after randomization (ie, postrandomization consent) are increasingly used, but debate on ethics persists because control arm patients are not specifically informed about the trials and randomization occurs before consent for the trials. The public's attitude toward postrandomization consent trials is unknown, but the way the trials are described could bias people's views.

Objectives

To assess the attitudes of the US general public toward postrandomization informed consent for pragmatic trials and to measure potential framing and other factors associated with those attitudes.

Design, setting, and participants

An online, 2 × 2 experimental survey (fielded between February 23 and April 3, 2018) portraying 4

SUBMITTER: Miller DG 

PROVIDER: S-EPMC6324565 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature