Spotlight on fevipiprant and its potential in the treatment of asthma: evidence to date.

ABSTRACT: Asthma is a heterogeneous disease, which may be classified into phenotypes and endotypes based on clinical characteristics and molecular mechanisms. The best described endotype of severe asthma is type 2 (T2)-high asthma, characterized by release of inflammatory cytokines by T helper 2 (T_H2) cells and type 2 innate lymphoid cells cells. Prostaglandin D2 contributes to T2 inflammation through binding of the G-protein-coupled receptor chemoattractant receptor-homologous molecule expressed on T_H2 cells (CRTH2). Fevipiprant is an oral competitive antagonist of CRTH2. Early-phase trials have demonstrated safety and potential efficacy in patients with asthma, specifically, improvement in FEV₁ and eosinophilic airway inflammation. However, no clear biomarker ident

SUBMITTER: Kao CC 

PROVIDER: S-EPMC6324611 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature