Association of Intraventricular Hemorrhage and Death With Tocolytic Exposure in Preterm Infants.

ABSTRACT:

Importance

No trials to date have demonstrated the benefits of tocolysis on death and/or neonatal morbidity in preterm infants; tocolytics may affect the fetal blood-brain barrier.

Objectives

To assess the risks associated with tocolysis in women delivering prematurely as measured by death and/or intraventricular hemorrhage (IVH) in preterm infants and to compare the association of calcium channel blockers (CCBs) nifedipine and nicardipine hydrochloride vs atosiban used for tocolysis with death and/or IVH.

Design, settings, and participants

The French 2011 EPIPAGE-2 (Enquête Épidémiologique sur les Petits Âges Gestationnels) cohort was limited to mothers admitted for preterm labor without fever, who delivered from 24 to 31 weeks of gestation from April 1 through Decem

SUBMITTER: Pinto Cardoso G 

PROVIDER: S-EPMC6324618 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature