Association of Continuation of Statin Therapy Initiated Before Transition to Chronic Dialysis Therapy With Mortality After Dialysis Initiation.

ABSTRACT:

Importance

De novo statin therapy in patients receiving chronic dialysis has failed to demonstrate cardiovascular (CV) protection in randomized clinical trials and thus is not recommended by current guidelines. However, current guidelines recommend the continuation of statin therapy if initiated before transition to dialysis.

Objective

To investigate whether the continuation of statins from advanced chronic kidney disease into the dialysis therapy period is associated with improved survival.

Design, setting, and participants

Retrospective cohort study of US veterans transitioning to dialysis between October 1, 2007, and March 30, 2014. Participants were 14 298 US veterans who were receiving statins during the 12-month period before transition to dialysis and survived

SUBMITTER: Streja E 

PROVIDER: S-EPMC6324660 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature