Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer.

ABSTRACT: The enhanced expression of the Y-box binding protein YBX1 is consistently correlated with poor outcomes or reduced survival of breast cancer patients. However, the mechanism underlying the association between increased YBX1 expression and poor outcomes has yet to be revealed. We searched a database for the top 500 genes that are positively or negatively correlated with YBX1 and with ESR1 in breast cancer patients. We further examined the association between YBX1-correlated genes and breast cancer outcomes in patients at Kyushu University Hospital. More than 60% of genes that are positively correlated with YBX1 are also negatively correlated with ESR1. The enhanced expression levels of the top 20 positively correlated genes mostly predict negative outcomes, while the enhanced expression lev

SUBMITTER: Shibata T 

PROVIDER: S-EPMC6324687 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature