Neuroendocrine stress response is moderated by sex and sex hormone receptor polymorphisms.

ABSTRACT: Sex hormones are significant regulators of stress reactivity, however, little is known about how genetic variation in hormone receptors contributes to this process. Here we report interactions between biological sex and repeat polymorphisms in genes encoding sex hormone receptors, and their effects on salivary cortisol reactivity in a sample of 100 participants (47 men & 53 women; 24.7 ± 3.23 years). Three genes were investigated: estrogen receptors alpha (ESR1) and beta (ESR2), and the androgen receptor (AR). Participants were classified as carrying 'Short' or 'Long' alleles based on median splits of the repeat distribution for each gene. Measures of physiological reactivity were collected before and after exposure to a canonical laboratory stressor and converted to traditional summary me

SUBMITTER: Hastings WJ 

PROVIDER: S-EPMC6324727 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature